1. a religious orientation of doubt; a denial of ultimate knowledge of the existence of God - agnosticism holds that you can neither prove nor disprove God's existence • Hypernyms: religious orientation 2. the disbelief in any claims of ultimate knowledge • Syn: skepticism, scepticism • Derivationally related forms: sceptical (for: scepticism), skeptical (for: skepticism) • Hypernyms: unbelief, disbelief